Salvage radical prostatectomy is the removal of the prostate in the event of local recurrence after radiation therapy. It requires an individual consideration of the risks and opportunities for each patient. As a prerequisite, the treating urologist must provide extensive advice as to whether all necessary criteria for an operation are fulfilled. The risk of complications is slightly higher for salvage operations than for primary radical prostatectomies due to the prior damage to the tissue caused by radiation. However, in experienced centers such as the Martini-Klinik the complication rate is only slightly higher. In principle and on the basis of individual medical indication, salvage operations are possible for prostate cancer after other therapies such as HIFU, cryo, laser or thermo therapy.