Measurable PSA-value despite operation or radiation therapy

Hope even at an advanced stage

If, after prostate surgery or radiation therapy, the illness has not been cured and subsequently metatstasizes, or if the first diagnosis had already detected metastases in bones, lymph nodes or organs, then medication therapy should be used against the tumor. As regards the latter, the benefits of additional local treatment (radiation or surgery) should be carefully examined.

The effect of the hormone testosterone can be countered by the admission of so-called antiandrogens as tablets. As an alternative to the therapy with antiandrogens so-called GnRH analogues or GnRH antagonists, administered as depot injections, can be used for hormone-withdrawal therapy. This medication prevents the production of testosterone in the testicles. 

Of course, testosterone withdrawal entails side-effects. Therefore, it must be considered individually under which personal circumstances medication therapy with hormone withdrawal makes sense.

Beyond hormone withdrawal therapy - the castration-resistant tumor

During hormone withdrawal the tumor might spread after an average period of 24 months. This situation is then termed the "castration-resistant" tumor stage. Currently, several new substances with various effect mechanisms which can be prescribed for patients with metastasized, castration-resistant prostate cancer. The decision regarding which of the new substances are to be used at which stage of the illness must be taken with careful consideration of age, the characteristics of the tumor, as well as the benefits and side-effects of the medication.

Your urologist should decide how to react in the event of a PSA-relapse.